“The activation of the tanning/pigmentation pathway by this new class of small molecules is physiologically identical to UV-induced pigmentation without the DNA-damaging effects of UV,” says David E. Fisher, MD,
Tag: IT News Update
Risky bingeing: Women in Appalachian Ohio report higher rates of alcohol misuse
Compared with women living in urban areas, women who reside in these rural areas face multiple health concerns, including substance abuse issues, and often at greater rates. While the opioid
Where cigarette smoking’s damage is done — down to your DNA
The innovation comes from the laboratory of Nobel laureate Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics at UNC’s School of Medicine. In a study
Scientists solve a mystery in cellular ‘droplet’ organelles
These droplet-like structures are commonly known as membraneless organelles, and they are key to how cells compartmentalize their biochemistry and regulate processes such as gene expression and response to stress.
Drug developed for arthritis could be first to stop heart valve calcification
Today in Circulation, the journal of the American Heart Association, Vanderbilt University researchers published findings that the drug — a monoclonal antibody known as SYN0012 — shows promise in keeping
Screening for both genetic diseases, chromosomal defects with a single biopsy improves pregnancy rates, say researchers
By doing this, only embryos that are free not only of the genetic disease, but also of chromosomal abnormalities (aneuploidy), would be transferred to a woman’s womb, giving her the
Naltrexone: Injectable or oral?
Fifty-four veterans diagnosed with alcohol use disorder were recruited from a larger population of 113 veterans hospitalized for an acute medical or psychiatric illness. Participants were randomly divided into two
Western diet increases Alzheimer’s pathology in genetically predisposed mice
Individuals who inherit the gene APOE4 — approximately 12 percent of the U.S. population — have an increased risk of late-onset AD, but not all carriers develop the disease. Although
‘DNA is a bully’ that hustles transcribers to targets
New simulations of DNA as a transport conduit could shatter the way scientists have thought about how large molecules called transcription factors diffuse on their way to carry out genetic
Combining radionuclide therapy with a PARP inhibitor slows neuroendocrine tumor growth
The Canadian study evaluated lutetium-177 (177Lu)-octreotate PRRT, which has been found effective for slowing the growth of malignant peptide-receptor positive NETs. The challenge is that damaged cells can naturally repair
Personalized PRRT improves radiation delivery to neuroendocrine tumors
PRRT has become a treatment of choice for relatively rare and easy-to-overlook neuroendocrine tumors (NETs). The targeted treatment is designed to home in on and attach to peptide-receptor positive tumors,
Lab on a chip could monitor health, germs and pollutants
Rutgers engineers have invented biosensor technology — known as a lab on a chip — that could be used in hand-held or wearable devices to monitor your health and exposure
Lab on a chip could monitor health, germs and pollutants
Rutgers engineers have invented biosensor technology — known as a lab on a chip — that could be used in hand-held or wearable devices to monitor your health and exposure
Healthy diet? That depends on your genes
Before the Neolithic revolution that began around 10,000 years ago, European populations were hunter-gatherers that ate animal-based diets and some seafood. But after the advent of farming in southern Europe
CT angiography appears better at predicting future risk for patients with chest pain
“We do show that obstructive coronary artery disease and myocardial ischemia remain the strongest predictors of future cardiovascular events, but for the first time, in a randomized comparison we demonstrate
